A co-worker plugged in her iPhone into the Mac that her phone doesn't normally sync with. Somehow (I am not sure of how), it put the phone into DFU mode.
Her first question when she brought it to me: Did I lose the photos I took this morning of my daughter's first day of kindergarten? Her last iCloud backup was last night at 11:03 PM.
Update: Photo stream hadn't grabbed those photos because she hadn't been on WiFi yet.